RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
DDAH1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; Dual-luciferase reporter assay etc.
Target
DDAH1
Pathway
NA
PubMed ID
Title
MiR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia
Year
2014
Function
"Hypoxia inhibited DDAH1 and DDAH2 expression and increased ADMA levels in cultured human pulmonary endothelial cells. In contrast, in human pulmonary smooth muscle cells, only DDAH2 was reduced whereas ADMA levels remained unchanged. Endothelium-specific down-regulation of DDAH1 by miR-21 in hypoxia induced endothelial dysfunction and was prevented by overexpression of DDAH1 and miR-21 blockade. DDAH1, but not DDAH2, mRNA levels were reduced, whereas miR-21 levels were elevated in lung tissues from patients with pulmonary arterial hypertension and mice with pulmonary hypertension exposed to 2 weeks of hypoxia."